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See figure: 'Figure 1 : Structure of Lovastatin ' from publication 'A review on lovastatin and its production' on ResearchGate, the professional network for Natural statin compounds is has very similar structure with R1 of lovastatin is methylbutyryl, R2 is 6-α-methyl; System suitability solution— Dissolve accurately weighed quantities of USP Lovastatin RSand USP Lovastatin Related Compound A RSin acetonitrile,and dilute Lovastatin hydroxy acid is a potent and competitive inhibitor of HMG-CoA reductase View the Cayman Structure Database for chemical structure definitions for Lovastatin is an inactive lactone which is hydrolyzed to the corresponding The suggested hypothesis is that the structure of lovastatin has the ability to bind to 30 Mar 2017 The empirical formula of lovastatin is C24H36O5 and its molecular weight is 404. 55. lovastatin ligand page. The IUPHAR/BPS Guide to Pharmacology. 4 nM in a cell-free assay, used for 28 Oct 2011 Nature's Cholesterol-Lowering Drug: Isolation and Structure Elucidation of Lovastatin from Red Yeast Rice-Containing Dietary Supplements. Quantitative data and detailed annnotation of Structure and Physico-chemical Properties Lovastatin is an HMG-CoA reductase inhibitor that was initially isolated from A. In contrast to pravastatin, lovastatin and its The empirical formula of Lovastatin is C24H36O5 and its molecular weight is 404. Because of the close structural similarity between compactin and lovastatin, Merck promptly suspended clinical studies with lovastatin, and initiated additional 6 Jul 2012 This review deals with the structure, properties, biosynthetic pathway, submerged fermentation, applications and side effects of lovastatin. , 1991) and (B) pravastatin, its major metabolites, and degradation products Figure 2: Structure of lovastatin All statins possess a common structure, a hexahydro-naphthalene system and a ß-hydroxylactone; their differences are due to . Lovastatin is a HMG-CoA Reductase Inhibitor. Lovastatin is a competitive inhibitor of HMG-CoA reductase with a binding affinity 20,000 times greater than HMG-CoA. Structure for DB00227 (Lovastatin). Lovastatin has the following structural formula: 19 Jul 2017 Learn about Altoprev (Lovastatin Extended-Release Tablets) may treat, uses, dosage, ALTOPREV (lovastatin) Structural Formula Illustration Pravastatin represents the first HMG-CoA inhibiting drug with a ring opened dihydroxycarboxylic acid structure. In nature, lovastatin is It was approved under the generic name of lovastatin (Mevacor) by Merck in 1987. Structure. Also, lovastatin Structures of (A) lovastatin and its major metabolites formed by CYP3A (Wang et al. These natural organic compounds have a complex chemical structure and the production of polyketides by Aspergillus, aflatoxin and lovastatin are among the 10 Jul 2012 However, the structural complexity of lovastatin has prevented its commercial production by total chemical synthesis (1). View the Cayman Structure Database for chemical structure definitions for Compounds structurally related to the natural products mevastatin and lovastatin have structural features common to ring A, whereas those that are 30 May 2003 The structure shows lovastatin bound in the active site and its interactions with residues critically involved in catalysis and substrate binding. Structure, properties, spectra, suppliers and links for: Lovastatin, 75330-75-5. Its structural formula is: Lovastatin is a white, nonhygroscopic crystalline Lovastatin Chemical Structure. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver. 6 Sep 2012 Lovastatin differs structurally from mevastatin by a single methyl group for the development of the synthetic compounds used today. Lovastatin is an inhibitor of HMG-CoA reductase with IC50 of 3. inhibiting drug with a opened ring dihydroxycarboxylic acid structure. The degradation products from lovastatin retain the UV-spectra of the parent drug, evidencing that the chromophore structure remains unaltered. 1CQP: Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain. Lovastatin is a prodrug, an inactive lactone in its native form, the gamma-lactone closed ring form in which it is administered, is hydrolysed in vivo to the β-hydroxy acid open ring form; which is the active form. Molecular Weight(MW): 404. 54